Metabolic Research Peptides

5-Amino-1MQ

5-Amino-1-methylquinolinium

5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N-methyltransferase (NNMT). NNMT is a very important component in metabolism and energy and is predominantly active in fat tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1). SIRT1 is also known as the "longevity gene" because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer. Research in mice given 5-amino-1MQ showed a 7% reduction in body mass over 10 days without any changes in food intake, compared to controls. Research has shown that decreasing NNMT may help shrink fat cells and reduce the size of fat deposits.

Formula

C₁₀H₁₁N₂

MW

159.21 g/mol

Purity

99% HPLC

Length

—

5-amino-1MQ is a small molecule capable of blocking the activity of nicotinamide N-methyltransferase (NNMT).

Adipotide

Adipotideftpp

Adipotide, also known as FTPP, is an experimental weight loss treatment that kills fat cells by targeting the blood supply of those cells.

Formula

C₁₅₂H₂₅₂N₄₄O₄₂

MW

2611.41 g/mol

Purity

99% HPLC

Length

28 aa

Adipotide, also known as FTPP, is an experimental weight loss treatment that kills fat cells by targeting the blood supply of those cells.

AOD-9604

Anti-Obesity Peptide 9604

AOD9604 is a modified version of the hGH fragment 176-191 peptide (contains a di-sulfide bridge) and thus a derivative of human growth hormone (hGH). Originally developed as a lipolytic (fat burning) compound, AOD9604 has shown benefit in studies of heart disease, osteoarthritis/cartilage repair, and metabolic syndrome. AOD9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis in animal studies.

Formula

C₇₈H₁₂₃N₂₃O₂₃S₂

MW

1815.12 g/mol

Purity

99% HPLC

Length

—

AOD9604 is a modified version of the human growth hormone (hGH) peptide fragment 176–191 (incorporating a disulfide bond) and is, therefore, a derivative of human growth hormone (hGH).

IGF-1 LR3

Long R3 Insulin-like Growth Factor-1

IGF-1 LR3 Receptor Grade is a premium research reagent for use in cell growth studies, IGF receptors and IGF binding proteins and is more potent than rH IGF1 and media grade IGF1. (Standard IGF1-LR3.)

Formula

C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

MW

9117.50 g/mol

Purity

99% HPLC

Length

83 aa

IGF-1 receptor signaling, cell growth, cell differentiation, and metabolic regulation.

Kisspeptin-10

Kisspeptin acts to control hormone secretion as it relates to reproduction. Kisspeptin has been shown to influence testosterone levels and sex-related behaviors like drive and motivation. Research also suggests it may help to reverse some of the effects of aging.

Formula

C₆₃H₈₃N₁₇O₁₄

MW

1302.40 g/mol

Purity

99% HPLC

Length

10 aa

Research on reproductive endocrine regulation, GnRH (gonadotropin-releasing hormone) secretion, and signaling within the reproductive axis.

MOTS-c

MOTS-c is a mitochondrial-derived peptide (MDP) composed of 16 amino acids, which plays a critical role in cellular metabolic regulation. Synthesized within mitochondria, MOTS-c functions by modulating the cellular energy balance through pathways involved in glucose metabolism, insulin sensitivity, and cellular stress response. MOTS-c exerts its effects by translocating to the nucleus, where it influences the expression of genes related to mitochondrial biogenesis and metabolic regulation, particularly under conditions of metabolic stress. Research has shown this peptide to improve exercise capacity, reduce obesity, insulin resistance and other disease processes such as osteoporosis and the mitigation of metabolic disorders and age-associated diseases.

Formula

C₁₀₁H₁₅₂N₂₈O₂₂S₂

MW

2174.64 g/mol

Purity

99% HPLC

Length

16 aa

Mitochondrial function, energy metabolism, glucose metabolism, insulin sensitivity, and cellular stress responses.

NAD+

Nicotinamide Adenine Dinucleotide

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in all living cells, essential for metabolic processes and cellular function. It acts as a mediator of redox reactions, alternating between its oxidized (NAD+) and reduced (NADH) forms to facilitate electron transfer, crucial for energy production and sustaining life. Involved in over 500 enzymatic reactions, NAD+ is central to maintaining cellular homeostasis. Research shows that NAD+ may be beneficial in improving muscle function, protecting cells of the nervous system, and generally reducing the effects of aging. Beyond energy metabolism, NAD+ supports DNA repair and gene regulation through enzymes like sirtuins and PARPs. Sirtuins use NAD+ to regulate cellular functions such as DNA repair, gene expression, and aging, while PARPs utilize it to repair DNA damage and maintain genomic stability. These roles underscore NAD+'s importance in cellular integrity and combating aging.

Formula

C₂₁H₂₇N₇O₁₄P₂

MW

663.43 g/mol

Purity

99% HPLC

Length

—

Cellular energy metabolism, mitochondrial function, redox reactions, and cellular senescence.

Retatrutide

Retatrutide

Retatrutide is a synthetic 39-amino acid peptide engineered to act simultaneously on three receptors: the GLP-1, GIP, and glucagon receptors. By activating all three incretin and glucagon signaling pathways, it is used to model how combined receptor signaling influences energy balance in preclinical systems. Common research applications include: Metabolism and energy expenditure models Incretin receptor pharmacology Comparative studies involving mono-agonist and dual-agonist peptides

Formula

C256H392N64O79

MW

4731.20 g/mol

Purity

Purity ≥99% by HPLC · Certificate of Analysis available

Length

39 aa

Metabolism and Energy Expenditure Models Incretin Receptor Pharmacology Comparative Studies of Mono-agonist and Dual-agonist Peptides

SEMAGLUTIDE

SEMAGLUTIDE

Semaglutide: GLP-1 receptor agonist for laboratory research. Third-party tested, 99%+ purity, COA available.

31-residue GLP-1 receptor agonist …

Formula

C187H291N45O59

MW

4113.58 g/mol

Purity

≥99% by HPLC · COA available

Length

31 aa

Metabolism and Energy Expenditure Models Incretin Receptor Pharmacology Comparative Studies of Mono-agonist and Dual-agonist Peptides

Tirzepatide

Tirzepatide

Tirzepatide: dual GIP / GLP-1 receptor agonist for laboratory research. Third-party tested, 99%+ purity, COA available.

39-residue GIP/GLP-1 dual agonist;…

Formula

C225H348N48O68

MW

4813.45 g/mol

Purity

≥99% by HPLC · COA available

Length

39 aa

Tirzepatide is a 39-amino-acid peptide that activates both the GIP and GLP-1 receptors. Its dual activity makes it a standard tool for comparing single-pathway and dual-pathway incretin signaling.