Longevity & Aging Research Peptides

AICAR

AR50 AICAR

AICAR is an analogue of adenosine monophosphate. It has been used clinically to protect against cardiac ischemia following heart attack. AICAR has antioxidant properties and may therefore help to slow the physiologic signs of aging. There is ongoing research into the use of AICAR to mediate the effects of diabetes, auto-immune diseases, and other inflammatory conditions

Formula

C₉H₁₅N₄O₈P

MW

338.21 g/mol

Purity

99% HPLC

Length

—

AICAR is an analogue of adenosine monophosphate. It has been used clinically to prevent myocardial ischemia following a heart attack.

FOXO4-DRI

FOX04-DRI (Retro-Inverso) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. FOXO4-DRI has been shown in research to prevent normal FOXO4 binding to p53, thereby allowing for elimination of senescent cells, improved organ function, and younger tissue “biological age.” FOXO4-DRI impacts insulin signaling, cell cycle regulation, and oxidative stress signaling pathways. FOXO4-DRI is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in animal studies.

Formula

C₂₂₈H₃₈₈N₈₆O₆₄

MW

5358.05 g/mol

Purity

99% HPLC

Length

46 aa

Cellular senescence, senolysis (clearance of senescent cells), and the FOXO4-p53 protein interaction.